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Grass-specific CD4(+) T-cells exhibit varying degrees of cross-reactivity, implications for allergen-specific immunotherapy.

Authors
  • Archila, L D
  • DeLong, J H
  • Wambre, E
  • James, E A
  • Robinson, D M
  • Kwok, W W
Type
Published Article
Journal
Clinical & Experimental Allergy
Publisher
Wiley (Blackwell Publishing)
Publication Date
Jul 01, 2014
Volume
44
Issue
7
Pages
986–998
Identifiers
DOI: 10.1111/cea.12324
PMID: 24708411
Source
Medline
Keywords
License
Unknown

Abstract

Our results suggest that not all Pooideae grass epitopes with sequence homology are cross-reactive. Non-cross-reactive T-cells with comparable frequency, phenotype and functionality to Phl p-specific T-cells suggest that a multiple allergen system should be considered for immunotherapy instead of a mono-allergen system.

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