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Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin.

Authors
Type
Published Article
Journal
Clinical pharmacology and therapeutics
Publication Date
Volume
66
Issue
2
Pages
118–127
Identifiers
PMID: 10460065
Source
Medline

Abstract

Grapefruit juice significantly increased serum concentrations of atorvastatin acid, atorvastatin lactone, and active and total HMG-CoA reductase inhibitors, probably by decreasing CYP3A4-mediated first-pass metabolism of atorvastatin in the small intestine. On the other hand, grapefruit juice had no effect on the pharmacokinetics of pravastatin. Concomitant use of atorvastatin and at least large amounts of grapefruit juice should be avoided, or the dose of atorvastatin should be reduced accordingly.

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