Affordable Access

deepdyve-link
Publisher Website

Granulocyte/monocyte adsorptive apheresis for the treatment of therapy-refractory chronic active ulcerative colitis.

Authors
  • Dignass, Axel1
  • Akbar, Ayesha2
  • Baumgart, Daniel C3
  • Bommelaer, Gilles4
  • Bouguen, Guillaume5
  • Cadiot, Guillaume6
  • Gillessen, Anton7
  • Grimaud, Jean-Charles8
  • Hart, Ailsa2
  • Hoque, Syed9
  • Makins, Richard10
  • Michiels, Christophe11
  • Moreau, Jacques12
  • Premchand, Purushothaman13
  • Ramlow, Wolfgang14
  • Schanz, Stefan15
  • Subramanian, Sreedhar16
  • von Tirpitz, Christian17
  • Bonaz, Bruno18
  • 1 a Department of Gastroenterology, Hepatology, Oncology and Metabolic Diseases , Markus-Krankenhaus , Frankfurt/Main , Germany. , (Germany)
  • 2 b IBD Unit, St. Mark's Hospital and Academic Institute , London , UK.
  • 3 c Department of Medicine, Division of Gastroenterology and Hepatology , Charité Medical Center - Virchow Hospital, Medical School of the Humboldt-University of Berlin , Berlin , Germany. , (Germany)
  • 4 d Service Hépatologie-Gastroentérologie, CHU Clermont-Ferrand , Clermont-Ferrand , France. , (France)
  • 5 e Service des Maladies de l'Appareil Digestif et CIC1414, University Hospital of Rennes , Pontchaillou , France. , (France)
  • 6 f Service d'Hépato-gastro-entérologie, CHU du Reims, Hôpital Robert Debré , Reims Cedex , France. , (France)
  • 7 g Herz-Jesu-Krankenhaus, Hiltrup GmbH , Münster , Germany. , (Germany)
  • 8 h Assistance Publique Hôpitaux de Marseille , Marseille , France. , (France)
  • 9 i Barts Health NHS Trust, Whipps Cross University Hospital , London , UK.
  • 10 j Cheltenham General Hospital , Gloucestershire , UK.
  • 11 k Service Hepato-Gastro-Enterologie, CHU Le Bocage , Dijon , France. , (France)
  • 12 l Hôpital Rangueil, Pôle Digestif , Toulouse , France. , (France)
  • 13 m Clinical Diagnostic Unit, Queens Hospital , Romford , UK.
  • 14 n Clinic for Nephrology, Dialysis and Apheresis , Rostock , Germany. , (Germany)
  • 15 o Kriesklinikum Siegen , Siegen , Germany. , (Germany)
  • 16 p Department of Gastroenterology , Royal Liverpool University Hospital , Liverpool , UK.
  • 17 q Medizinische Klinik - Gastroenterologie Kreisklinik , Biberach , Germany. , (Germany)
  • 18 r Clinique Universitaire d'Hépato-Gastroentérologie, CHU Grenoble , Grenoble , France. , (France)
Type
Published Article
Journal
Scandinavian Journal of Gastroenterology
Publisher
Informa UK (Taylor & Francis)
Publication Date
Apr 01, 2018
Volume
53
Issue
4
Pages
442–448
Identifiers
DOI: 10.1080/00365521.2018.1447598
PMID: 29513111
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Current options for patients with steroid-dependent, chronic-active ulcerative colitis (UC) with insufficient response/intolerance to immunosuppressants (ISs) and/or biologics are limited. The aim of this study was to assess the long-term outcome of granulocyte/monocyte adsorptive (GMA) apheresis (Adacolumn®) in this population. Ninety five adults with steroid-dependent active UC and insufficient response/intolerance to IS and/or TNF inhibitors received 5-8 aphereses in a single induction series of ≤10 weeks. Endpoints included rates of remission (clinical activity index [CAI] ≤ 4) at weeks 24 and 48. Of 94 patients (ITT population), remission and response rates were 34.0% and 44.7% at week 24, and 33.0% and 39.4% at week 48. Among 30 patients with prior failure of IS and biologics, 33.3% and 20.0% were in remission at weeks 24 and 48. At both weeks, 19.2% of patients achieved steroid-free remission. Sustained remission or response occurred in 27.7% of patients at 48 weeks. The cumulative colectomy rate at week 96 was 23.4%. Safety was consistent with previous findings. This study confirms findings of the 12-week interim analysis and demonstrates that GMA apheresis provides a safe and beneficial long-term outcome for patients with chronic active UC resistant/intolerant to IS and/or TNF inhibitors.

Report this publication

Statistics

Seen <100 times