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Granulocyte colony-stimulating factor: its potential role in infectious disease.

Authors
Type
Published Article
Journal
AIDS
0269-9370
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Volume
13 Suppl 2
Identifiers
PMID: 10596675
Source
Medline

Abstract

Studies on the role of endogenous granulocyte colony-stimulating factor (G-CSF) in host defense indicate that, in addition to its anti-infectious role, this cytokine has an immunomodulatory function and also augments antibiotic efficacy. Pre-clinical and clinical trials with Filgrastim, recombinant-methionyl human G-CSF, in neutropenic and non-neutropenic infections demonstrate a reduction in morbidity and mortality. This is attributed to Filgrastim's ability to control infectious complications and permit continuation of immunosuppressive therapies.

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