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Granulocyte colony-stimulating factor has no adverse effects on atherosclerotic lesions in high cholesterol-fed miniature Swine.

Authors
  • Takai, Hirotake
  • Miyoshi, Akio
  • Yamazaki, Masaki
  • Adachi, Kenji
  • Katagiri, Kouichi
  • Arakawa, Hitoshi
  • Katsuyama, Kiyoka
  • Ito, Tsuneo
  • Fujii, Etsuko
  • Hayashi, Shuji
  • Kato, Atsuhiko
  • Suzuki, Masami
Type
Published Article
Journal
The Journal of veterinary medical science / the Japanese Society of Veterinary Science
Publication Date
Sep 01, 2008
Volume
70
Issue
9
Pages
943–950
Identifiers
PMID: 18840969
Source
Medline
License
Unknown

Abstract

Granulocyte colony-stimulating factor (G-CSF) is widely used to mobilize peripheral blood stem cells, and expected to restore cardiac function for patients with coronary artery diseases as a consequence of progression of atherosclerosis. Safety issues related to the administration of G-CSF to these patients, however, are still under study. The animal model for atherosclerosis was produced by feeding miniature swine a high-cholesterol diet for 3 months. G-CSF (5 or 10 microg/kg/day) was given to the animal model by daily subcutaneous injections for 10 days and 20 main arteries were evaluated pathologically. In addition, the general toxicological effects were studied on clinical signs, body weight, hematology, blood chemistry and pathology. In the G-CSF-treated groups, a variety of changes related to the major pharmacological activity of G-CSF including an increase in white blood cell (WBC) counts were observed. In many arteries, atherosclerotic lesions similar to Type I-V of the proposed classification by the American Heart Association were observed. No effects of the G-CSF treatment were seen on the histopathological findings, incidence, severity or distribution of atherosclerotic lesions. In addition, no infiltration of neutrophils to the lesions was observed. These findings suggest that the administration of G-CSF causes neither exacerbation or modification of atherosclerotic lesions nor adverse changes despite that a sufficient increase in WBC counts could be achieved in the peripheral blood.

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