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Graft nephrectomy in children

Authors
  • Phillips, Benedict L.1
  • Callaghan, Chris J.1
  • 1 Guy’s Hospital and the Evelina London Children’s Hospital, Department of Nephrology and Transplantation, London, UK , London (United Kingdom)
Type
Published Article
Journal
Pediatric Nephrology
Publisher
Springer-Verlag
Publication Date
Jun 19, 2017
Volume
33
Issue
6
Pages
947–955
Identifiers
DOI: 10.1007/s00467-017-3697-1
Source
Springer Nature
Keywords
License
Green

Abstract

Kidney transplantation is recognised as the gold standard treatment of end-stage renal disease in most children, with excellent graft survival rates. When graft failure occurs, renal transplant recipients (RTRs) have the option of removal of the transplant (graft nephrectomy [GN]), or leaving the failed transplant in situ. The aims of this review are to discuss the indications for GN, surgical techniques, outcomes after GN (including risks of allosensitisation and the impact on subsequent transplants), and the possible role of routine GN in the asymptomatic RTR with a failed renal allograft. Literature in both the pediatric and adult renal transplant fields is reviewed. We also discuss how future research in this area could advance our knowledge of which patients to select for GN, and the most appropriate surgical approach.

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