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gp96-Peptide Vaccination of Mice against Intracellular Bacteria

Authors
  • Ulrich Zügel
  • Anne-Marit Sponaas
  • Jutta Neckermann
  • Bernd Schoel
  • Stefan H. E. Kaufmann
Publisher
American Society for Microbiology
Publication Date
Jun 01, 2001
Source
PMC
Keywords
License
Unknown

Abstract

This work demonstrates that gp96 preparations isolated from cells infected with intracellular bacteria induce cytotoxic T-lymphocyte responses and confer protection. Our findings extend previous reports on the immunogenicity of gp96-associated peptides to antigens derived from intracellular bacteria. Immunization with gp96 may therefore represent a promising vaccination strategy against bacterial pathogens.

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