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The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome

Authors
  • Bourgneuf, Camille1, 2
  • Bailbé, Danielle3
  • Lamazière, Antonin1, 4
  • Dupont, Charlotte1, 2, 5
  • Moldes, Marthe1, 2
  • Farabos, Dominique1, 4
  • Roblot, Natacha1, 2
  • Gauthier, Camille1, 2
  • Mathieu d’Argent, Emmanuelle1, 2, 5
  • Cohen-Tannoudji, Joelle3
  • Monniaux, Danielle6
  • Fève, Bruno1, 2, 7
  • Movassat, Jamileh3
  • di Clemente, Nathalie1, 2
  • Racine, Chrystèle1, 2, 8
  • 1 Centre de Recherche Saint-Antoine (CRSA),
  • 2 Institut Hospitalo-Universitaire ICAN,
  • 3 UMR 8251, CNRS, F-75013,
  • 4 Département PM2,
  • 5 Assistance Publique des Hôpitaux de Paris, Hôpital Tenon, Service de biologie de la reproduction-CECOS, Paris, France
  • 6 IFCE,
  • 7 Service Endocrinologie, CRMR PRISIS,
  • 8 Université de Paris,
Type
Published Article
Journal
Nature Communications
Publisher
Springer Nature
Publication Date
Feb 16, 2021
Volume
12
Identifiers
DOI: 10.1038/s41467-021-21308-y
PMID: 33594056
PMCID: PMC7886868
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

Although polycystic ovary syndrome is the most common cause of female infertility, its etiology remains poorly understood. Here, the authors report a rat model that spontaneously exhibits the clinical heterogeneity of this syndrome and demonstrate that the phenotype is developmentally programmed.

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