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Gossypol, a potent inhibitor of arachidonate 5- and 12-lipoxygenases.

Authors
  • Hamasaki, Y
  • Tai, H H
Type
Published Article
Journal
Biochimica et Biophysica Acta
Publisher
Elsevier
Publication Date
Mar 27, 1985
Volume
834
Issue
1
Pages
37–41
Identifiers
PMID: 3919771
Source
Medline
License
Unknown

Abstract

Gossypol inhibited 5- and 12-lipoxygenases of rat basophilic leukemia (RBL-1) cells with ID50 of 0.3 microM and 0.7 microM, respectively. Nearly two orders of magnitude of higher concentration of gossypol was required to inhibit prostaglandin synthetase. The inhibition was of a non-competitive type with respect to arachidonate.

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