Affordable Access

Publisher Website

Goodnight, astrocyte: waking up to astroglial mechanisms in sleep.

Authors
  • Ingiosi, Ashley M1
  • Frank, Marcos G1
  • 1 Department of Translational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Type
Published Article
Journal
FEBS Journal
Publisher
Wiley (Blackwell Publishing)
Publication Date
May 01, 2023
Volume
290
Issue
10
Pages
2553–2564
Identifiers
DOI: 10.1111/febs.16424
PMID: 35271767
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Astrocytes mediate many important aspects of neural homeostasis, but until recently, their role in sleep was largely unknown. The situation has dramatically changed in the last decade. The use of transgenic animals, optogenetics, chemogenetics, brain imaging and sophisticated molecular assays has led to exciting discoveries. Astrocytes dynamically change their activity across the sleep-wake cycle and may encode sleep need via changes in intracellular signalling pathways. Astrocytes also exocytose/secrete sleep-inducing molecules which modulate brain activity, sleep architecture and sleep regulation. Many of these observations have been made in mice and Drosophila melanogaster, indicating that astroglial sleep mechanisms are evolutionarily conserved. We review recent findings and discuss future directions. © 2022 Federation of European Biochemical Societies.

Report this publication

Statistics

Seen <100 times