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Gonococci cause immunosuppression by engaging a coinhibitory receptor on T lymphocytes

Authors
  • Normark, Staffan1
  • Albiger, Barbara2
  • Jonsson, Ann-Beth1
  • 1 Microbiology and Tumor biology Center, Karolinska Institute, Stockholm, Sweden , Stockholm (Sweden)
  • 2 Swedish Institute for Infectious Disease Control, Stockholm, Sweden , Stockholm (Sweden)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Mar 01, 2002
Volume
3
Issue
3
Pages
210–211
Identifiers
DOI: 10.1038/ni0302-210
Source
Springer Nature
License
Yellow

Abstract

Gonococci that bind the coinhibitory receptor CEACAM1 appear to down-regulate the activation and proliferation of CD4+ T cells. Such infection-induced immunosuppression helps explain why there is little specific immune response associated with gonococcal disease.

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