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Gonadotropin-releasing hormone agonist binding in tiger salamander nasal cavity.

Authors
  • Wirsig-Wiechmann, C R
  • Jennes, L
Type
Published Article
Journal
Neuroscience Letters
Publisher
Elsevier
Publication Date
Oct 01, 1993
Volume
160
Issue
2
Pages
201–204
Identifiers
PMID: 8247354
Source
Medline
License
Unknown

Abstract

Binding of the iodinated gonadotropin-releasing hormone (GnRH) agonist, buserelin, was examined in the nasal cavities of tiger salamanders using in vitro autoradiography. Binding of [125I]buserelin was seen within the chemosensory epithelium of the main nasal cavity and Jacobson's (vomeronasal) organ. Highest levels of binding were observed over the chemosensory neuron dendrites. Given the apparent lack of GnRH-immunoreactive fibers within the chemosensory epithelium as we have observed in a previous study, these observations suggest that GnRH may diffuse from fibers in the lamina propria of the chemosensory mucosa into the sensory epithelium to modulate chemosensory reception.

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