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The gonadal function in obese adolescents: review

Authors
  • Condorelli, Rosita A.1
  • Calogero, Aldo E.1
  • Vicari, Enzo1
  • Mongioi’, Laura1
  • Favilla, Vincenzo2
  • Morgia, Giuseppe2
  • Cimino, Sebastiano2
  • Russo, Giorgio2
  • La Vignera, Sandro1
  • 1 University of Catania, Policlinico “G. Rodolico”, Section of Endocrinology, Andrology and Internal Medicine, Department of Medical and Pediatric Sciences, Via S. Sofia 78, Building 4, Room 2C18, Catania, 95123, Italy , Catania (Italy)
  • 2 University of Catania, Policlinico “G. Rodolico”, Department of Urology, Via S. Sofia 78, Building 4, Room 2C18, Catania, 95123, Italy , Catania (Italy)
Type
Published Article
Journal
Journal of Endocrinological Investigation
Publisher
Springer-Verlag
Publication Date
Jun 13, 2014
Volume
37
Issue
12
Pages
1133–1142
Identifiers
DOI: 10.1007/s40618-014-0107-4
Source
Springer Nature
Keywords
License
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Abstract

This review deals with the relationship between obesity in male adolescents and gonadal function. The article is structured in two main paragraphs; the first one is about population studies that have assessed puberty timing and its mode of onset in relation with body weight to evaluate if and how the latter can influence the gonadal function in this phase of life. These studies analyze issues such as increased BMI and early onset of male puberty, gender differences, secular trend toward early onset of puberty in males, effects of a different body composition on male puberty and consequences of a different stage of childhood obesity on the onset of male puberty. The second paragraph examines the possible mechanisms through which, obesity may alter the timing of puberty in young males, including the role of SHBG, leptin, insulin resistance, ghrelin, GH-IGF-1 axis, AR polymorphisms, primary testicular dysfunction, retinol binding protein 4 (RBP-4) and liver function abnormalities. However, despite the numerous studies in the literature, the etiology of gonadal disfunction in obese adolescents on puberty remains uncertain.

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