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Gold Nanorod-Based Engineered Cardiac Patch for Suture-Free Engraftment by Near IR.

Authors
  • Malki, Maayan1, 2
  • Fleischer, Sharon2, 3
  • Shapira, Assaf2, 3, 4
  • Dvir, Tal1, 2, 3, 4
  • 1 The Department of Materials Science and Engineering, Faculty of Engineering , Tel Aviv University , Tel Aviv 6997801 , Israel. , (Israel)
  • 2 The Center for Nanoscience and Nanotechnology , Tel Aviv University , Tel Aviv 6997801 , Israel. , (Israel)
  • 3 The School for Molecular Cell Biology and Biotechnology, Faculty of Life Sciences , Tel Aviv University , Tel Aviv 6997801 , Israel. , (Israel)
  • 4 Sagol Center for Regenerative Biotechnology , Tel Aviv University , Tel Aviv 6997801 , Israel. , (Israel)
Type
Published Article
Journal
Nano Letters
Publisher
American Chemical Society
Publication Date
Feb 08, 2018
Identifiers
DOI: 10.1021/acs.nanolett.7b04924
PMID: 29406721
Source
Medline
Keywords
License
Unknown

Abstract

Although cardiac patches hold a promise for repairing the infarcted heart, their integration with the myocardium by sutures may cause further damage to the diseased organ. To address this issue, we developed facile and safe, suture-free technology for the attachment of engineered tissues to organs. Here, nanocomposite scaffolds comprised of albumin electrospun fibers and gold nanorods (AuNRs) were developed. Cardiac cells were seeded within the scaffolds and assembled into a functioning patch. The engineered tissue was then positioned on the myocardium and irradiated with a near IR laser (808 nm). The AuNRs were able to absorb the light and convert it to thermal energy, which locally changed the molecular structure of the fibrous scaffold, and strongly, but safely, attached it to the wall of the heart. Such hybrid biomaterials can be used in the future to integrate any engineered tissue with any defected organs, while minimizing the risk of additional injury for the patient, caused by the conventional stitching methods.

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