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Go and stop signals for glial regeneration

Authors
  • Hidalgo, Alicia1
  • Logan, Ann2
  • 1 School of Biosciences, University of Birmingham, UK
  • 2 Neuroscience and Ophthalmology, College of Medicine and Dentistry, University of Birmingham, UK
Type
Published Article
Journal
Current Opinion in Neurobiology
Publisher
Current Biology
Publication Date
Dec 01, 2017
Volume
47
Pages
182–187
Identifiers
DOI: 10.1016/j.conb.2017.10.011
PMID: 29126016
PMCID: PMC6419527
Source
PubMed Central
License
Unknown

Abstract

The regenerative response of ensheating glia to central nervous system (CNS) injury involves proliferation and differentiation, axonal re-enwrapment and some recovery of behaviour. Understanding this limited response could enable the enhancement of it. In Drosophila , the glial progenitor state is maintained by Notch, an activator of cell division and Prospero (Pros), a repressor. Injury provokes the activation of NFκB and up-regulation of Kon-tiki (Kon), driving cell proliferation. Homeostatic switch-off comes about as two negative feedback loops involving Pros terminate the response. Importantly, the functions of the kon and pros homologues NG2 and prox1 , respectively, are conserved in mammalian NG2 glia. Controlling these genes is key for therapeutic manipulation of progenitors and stem cells to promote regeneration of the damaged CNS.

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