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GNE: a deep learning framework for gene network inference by aggregating biological information

Authors
  • KC, Kishan1
  • Li, Rui1
  • Cui, Feng2
  • Yu, Qi1
  • Haake, Anne R.1
  • 1 Golisano College of Computing and Information Sciences, Rochester Institute of Technology, 20 Lomb Memorial Drive, Rochester, New York, 14623, USA , Rochester, New York (United States)
  • 2 Thomas H. Gosnell School of Life Sciences, Rochester Institute of Technology, 84 Lomb Memorial Drive, Rochester, New York, 14623, USA , Rochester, New York (United States)
Type
Published Article
Journal
BMC Systems Biology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Apr 05, 2019
Volume
13
Issue
Suppl 2
Identifiers
DOI: 10.1186/s12918-019-0694-y
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundThe topological landscape of gene interaction networks provides a rich source of information for inferring functional patterns of genes or proteins. However, it is still a challenging task to aggregate heterogeneous biological information such as gene expression and gene interactions to achieve more accurate inference for prediction and discovery of new gene interactions. In particular, how to generate a unified vector representation to integrate diverse input data is a key challenge addressed here.ResultsWe propose a scalable and robust deep learning framework to learn embedded representations to unify known gene interactions and gene expression for gene interaction predictions. These low- dimensional embeddings derive deeper insights into the structure of rapidly accumulating and diverse gene interaction networks and greatly simplify downstream modeling. We compare the predictive power of our deep embeddings to the strong baselines. The results suggest that our deep embeddings achieve significantly more accurate predictions. Moreover, a set of novel gene interaction predictions are validated by up-to-date literature-based database entries.ConclusionThe proposed model demonstrates the importance of integrating heterogeneous information about genes for gene network inference. GNE is freely available under the GNU General Public License and can be downloaded from GitHub (https://github.com/kckishan/GNE).

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