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GM3 as a target of anti-lymphocytic ganglioside antibodies in AIDS patients.

Authors
  • Misasi, R
  • Sorice, M
  • Griggi, T
  • d'Agostino, F
  • Garofalo, T
  • Masala, C
  • Pontieri, G M
  • Lenti, L
Type
Published Article
Journal
Clinical immunology and immunopathology
Publication Date
Jun 01, 1993
Volume
67
Issue
3 Pt 1
Pages
216–223
Identifiers
PMID: 8500269
Source
Medline
License
Unknown

Abstract

IgG antibodies reacting with the GM3-comigrating band extracted from pooled AIDS lymphocytes were detected in 33.3% of AIDS patients sera, in 8% of asymptomatic anti-HIV-positive subjects, in none of the sera obtained from asymptomatic anti-HIV-negative drug abusers, from patients with acute B and chronic C hepatitis, and from healthy donors. All positive sera reacted selectively with the GM3-comigrating band obtained from AIDS lymphocytes but not with the corresponding band from normal lymphocytes. The lymphocytic ganglioside autoantigen was revealed as GM3. In addition, two main data were shown: (a) AIDS lymphocytes have an increased concentration of GM3 and (b) the ceramide of AIDS lymphocytic GM3 has a different percentual composition of fatty acids in contrast to control cells. It is suggested that these quantitative and qualitative changes might be responsible for the appearance of circulating anti-lymphocytic GM3 antibodies.

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