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Glypican 3 expression in pediatric malignant solid tumors.

Authors
  • Kinoshita, Yoshiaki
  • Tanaka, Sakura
  • Souzaki, Ryota
  • Miyoshi, Kina
  • Kohashi, Kenichi
  • Oda, Yoshinao
  • Nakatsura, Tetsuya
  • Taguchi, Tomoaki
Type
Published Article
Journal
European Journal of Pediatric Surgery
Publisher
Georg Thieme Verlag KG
Publication Date
Feb 01, 2015
Volume
25
Issue
1
Pages
138–144
Identifiers
DOI: 10.1055/s-0034-1393961
PMID: 25344940
Source
Medline
License
Unknown

Abstract

Most cases of hepatoblastoma and yolk sac tumor, and some cases of other tumors were found to express GPC3 either histologically or serologically. On the other hand, GPC3 was physiologically expressed during the fetal and neoinfantile period under 1 year of age. Although, more preliminary data and experience are required, patients older than 1 year that show a positive finding for GPC3 are considered to be appropriate candidates to receive the new immunotherapy using GPC3 peptide vaccination.

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