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[Glycosylation-dependent effector function of IgG antibodies].

Authors
  • Ehlers, M
Type
Published Article
Journal
Zeitschrift für Rheumatologie
Publication Date
Nov 01, 2012
Volume
71
Issue
9
Pages
798–800
Identifiers
DOI: 10.1007/s00393-012-1007-7
PMID: 23138557
Source
Medline
License
Unknown

Abstract

The Fc fragments of pathogenic IgG autoantibodies in patients with rheumatoid arthritis are low-galactosylated and low-sialylated. In contrast, high-galactosylated and high-sialylated antigen-specific IgG antibodies are sufficient to inhibit a pro-inflammatory immune response in an antigen-specific manner and might be a promising therapeutic tool to re-establish tolerance against defined self-antigens in autoimmune patients.

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