Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Glycosylated proteins preserved over millennia: N-glycan analysis of Tyrolean Iceman, Scythian Princess and Warrior.

Authors
  • Ozcan, Sureyya
  • Kim, Bum Jin
  • Ro, Grace
  • Kim, Jae-Han
  • Bereuter, Thomas L
  • Reiter, Christian
  • Dimapasoc, Lauren
  • Garrido, Daniel
  • Mills, David A
  • Grimm, Rudolf
  • Lebrilla, Carlito B
  • An, Hyun Joo
Type
Published Article
Journal
Scientific Reports
Publisher
Springer Nature
Publication Date
Jan 01, 2014
Volume
4
Pages
4963–4963
Identifiers
DOI: 10.1038/srep04963
PMID: 24831691
Source
Medline
License
Unknown

Abstract

An improved understanding of glycosylation will provide new insights into many biological processes. In the analysis of oligosaccharides from biological samples, a strict regime is typically followed to ensure sample integrity. However, the fate of glycans that have been exposed to environmental conditions over millennia has not yet been investigated. This is also true for understanding the evolution of the glycosylation machinery in humans as well as in any other biological systems. In this study, we examined the glycosylation of tissue samples derived from four mummies which have been naturally preserved: - the 5,300 year old "Iceman called Oetzi", found in the Tyrolean Alps; the 2,400 year old "Scythian warrior" and "Scythian Princess", found in the Altai Mountains; and a 4 year old apartment mummy, found in Vienna/Austria. The number of N-glycans that were identified varied both with the age and the preservation status of the mummies. More glycan structures were discovered in the contemporary sample, as expected, however it is significant that glycan still exists in the ancient tissue samples. This discovery clearly shows that glycans persist for thousands of years, and these samples provide a vital insight into ancient glycosylation, offering us a window into the distant past.

Report this publication

Statistics

Seen <100 times