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[Is glycosylated haemoglobin subject to rapid variations? Changes in insulin-dependent diabetic patients under a 24-hour artificial pancreas treatment (author's transl)].

Authors
Type
Published Article
Journal
La Nouvelle presse médicale
Publication Date
Volume
10
Issue
47
Pages
3839–3840
Identifiers
PMID: 7329794
Source
Medline

Abstract

According to recent studies, glycosylated haemoglobin (HbA1) is subject to rapid variations. In order to verify this point, nine insulin-dependent diabetic patients underwent a 24-hour normalization of glycaemia with an artificial pancreas. There was a non-significant decrease of HbA1 from 9.26 +/- 1.03 p. cent to 8.69 +/- 0.84 p. cent (mean +/- s.d.). An explanation to the apparent discrepancies between the different studies is proposed. The variations observed could largely be due to the inclusion or non inclusion in the assay methods of a subfraction of glycosylated haemoglobin: a Schiff's base likely to undergo glysosylation in a rapidly reversible manner.

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