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Glycophorin A somatic cell mutation frequencies in residents of Tibet at high altitudes.

Authors
  • Jensen, R H
  • Zhang, S
  • Wang, Z
  • Wang, W
  • Boice, J
Type
Published Article
Journal
Health physics
Publication Date
Oct 01, 1997
Volume
73
Issue
4
Pages
663–667
Identifiers
PMID: 9314228
Source
Medline
License
Unknown

Abstract

Since cosmic radiation is absorbed by the atmosphere surrounding the Earth, people who live at high altitude receive significantly larger amounts of cosmic radiation exposure than do those who live at low altitude. The glycophorin A-based somatic mutation assay was performed on 36 blood samples from two populations of Tibet inhabitants to determine whether residents at high altitude (4,300 m) accumulate more somatic mutations than do those who live at low altitude (1,500-1,900 m). These two populations differ in estimated cumulative lifetime cosmic radiation dose, with high altitude residents having received a mean of 111 mSv while low altitude residents received a mean of 27 mSv. Results showed no significant difference in peripheral blood variant erythrocyte frequency between these two populations and no difference from results of a previous study on Finnish workers who live at very low altitude (<500 m).

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