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Glycemic control modifies the association between microalbuminuria and c-reactive protein in Type 2 Diabetes Mellitus.

Authors
  • Bhowmick, Kaushik
  • Kutty, A V M
  • Shetty, H V
Type
Published Article
Journal
Indian journal of clinical biochemistry : IJCB
Publication Date
Sep 01, 2007
Volume
22
Issue
2
Pages
53–59
Identifiers
DOI: 10.1007/BF02913314
PMID: 23105683
Source
Medline
Keywords
License
Unknown

Abstract

Microalbuminuria and C-reactive protein reflect closely related components of the same disease process. The present study attempts to evaluate whether any association exists between C-reactive protein and microalbuminuria in Type 2 Diabetes Mellitus patients with poor and adequate glycemic control. It was observed that in diabetics with poor glycemic control, microalbuminuria showed a significant positive correlation with C-reactive protein and the prevalence of microalbuminuria was significantly more at elevated C-reactive protein levels. These parameters were not significant in subjects with adequately controlled disease. Further, there was a significant increase in levels of microalbuminuria in patients with poor glycemic control when compared to well-controlled diabetics at comparative levels of C-reactive protein. This study supports the hypothesis that endothelial dysfunction and inflammatory activity are involved in the pathogenesis of microalbuminuria and underscores the importance of glycemic control in the progression of inflammation in diabetes.

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