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Glycation Reduces the Stability of ApoAI and Increases HDL Dysfunction in Diet-controlled Type 2 Diabetes.

Authors
  • Kashyap, Sangeeta R1
  • Osme, Abdullah2
  • Ilchenko, Serguei2
  • Golizeh, Makan2
  • Lee, Kwangwon2
  • Wang, Shuhui3
  • Bena, James4
  • Previs, Stephen F5
  • Smith, Jonathan D3
  • Kasumov, Takhar2, 6
  • 1 Departement of Endocrinology and Metabolism, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195.
  • 2 Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272.
  • 3 Department of Cellular & Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195.
  • 4 Department of Quantitative Health Sciences, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195.
  • 5 Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033.
  • 6 Department of Hepatology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195.
Type
Published Article
Journal
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Publication Date
Oct 25, 2017
Identifiers
DOI: 10.1210/jc.2017-01551
PMID: 29077935
Source
Medline
License
Unknown

Abstract

The 2H2O method allows the detection of early in vivo impairments in HDL metabolism and function that are related to hyperglycemia-induced glycation of ApoAI in T2DM.

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