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Glycans in Immunologic Health and Disease

Authors
  • Zhou, Julie Y.
  • Cobb, Brian A.
Type
Published Article
Journal
Annual Review of Immunology
Publisher
Annual Reviews
Publication Date
Apr 26, 2021
Volume
39
Pages
511–536
Identifiers
DOI: 10.1146/annurev-immunol-101819-074237
Source
Annual Reviews
Keywords
License
Yellow

Abstract

The surfaces of all living organisms and most secreted proteins share a common feature: They are glycosylated. As the outermost-facing molecules, glycans participate in nearly all immunological processes, including driving host-pathogen interactions, immunological recognition and activation, and differentiation between self and nonself through a complex array of pathways and mechanisms. These fundamental immunologic roles are further cast into sharp relief in inflammatory, autoimmune, and cancer disease states in which immune regulation goes awry. Here, we review the broad impact of glycans on the immune system and discuss the changes and clinical opportunities associated with the onset of immunologic disease.

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