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Gluten-related neurologic dysfunction.

Authors
  • Hadjivassiliou, Marios
  • Duker, Andrew P
  • Sanders, David S
Type
Published Article
Journal
Handbook of clinical neurology
Publication Date
Jan 01, 2014
Volume
120
Pages
607–619
Identifiers
DOI: 10.1016/B978-0-7020-4087-0.00041-3
PMID: 24365341
Source
Medline
Keywords
License
Unknown

Abstract

The term gluten-related disorders (GRD) encompasses a spectrum of systemic autoimmune diseases with diverse manifestations. GRD are characterized by abnormal immunological responsiveness to ingested gluten in genetically susceptible individuals. Celiac disease (CD) or gluten-sensitive enteropathy is only one of a number of GRD. Extraintestinal manifestations include dermatitis herpetiformis (DH) and neurologic dysfunction. Furthermore it is only recently that the concept of extraintestinal manifestations without enteropathy has become accepted. In this chapter we review the spectrum of neurologic manifestations in GRD, discuss recent advances in their diagnosis, and look at their possible pathophysiologic mechanisms.

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