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Glutamine and regulation of gene expression in rat hepatocytes: the role of cell swelling.

Authors
Type
Published Article
Journal
Biochimie
0300-9084
Publisher
Elsevier
Publication Date
Volume
80
Issue
10
Pages
807–811
Identifiers
PMID: 9893939
Source
Medline

Abstract

Glutamine is able to regulate the expression of various genes in rat hepatocytes. This includes genes coding for proteins involved in glutamine utilization, such as argininosuccinate synthetase (ureagenesis) or phosphoenolpyruvate carboxykinase (gluconeogenesis). Moreover, glutamine is also able to stimulate the expression of genes involved in the acute-phase response, such as the alpha 2-macroglobulin gene. The effect of glutamine on the regulation of gene expression may be explained, at least in part, by the cell swelling due to its sodium-dependent transport. The physiological significance of the effect of glutamine is discussed.

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