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Glucose tolerance and insulin secretion in spontaneously hyperthyroid cats.

Authors
  • Hoenig, M1
  • Peterson, M E
  • Ferguson, D C
  • 1 Department of Physiology and Pharmacology and Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602.
Type
Published Article
Journal
Research in Veterinary Science
Publisher
Elsevier
Publication Date
November 1992
Volume
53
Issue
3
Pages
338–341
Identifiers
PMID: 1465507
Source
Medline
License
Unknown

Abstract

Glucose tolerance and insulin secretion after administration of a glucose load were determined in 11 clinically normal cats and 15 cats with spontaneous hyperthyroidism. In six hyperthyroid cats, a glucose tolerance test was repeated after treatment with radioactive iodine (131I). All cats had similar baseline glucose concentrations. However, the cats with hyperthyroidism had a significantly decreased glucose clearance, which was worse after treatment. Hyperthyroidism also caused a marked increase in basal and glucose-stimulated insulin secretion, which was not improved with treatment. It is concluded that hyperthyroidism in cats may lead to long-lasting alterations of glucose tolerance and insulin secretion which may not be reversed by treatment.

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