Affordable Access

Glucocorticoids potentiate ischemic injury to neurons: therapeutic implications.

Authors
  • Sapolsky, R M
  • Pulsinelli, W A
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Sep 27, 1985
Volume
229
Issue
4720
Pages
1397–1400
Identifiers
PMID: 4035356
Source
Medline
License
Unknown

Abstract

Sustained exposure to glucocorticoids, the adrenocortical stress hormones, is toxic to neurons, and such toxicity appears to play a role in neuron loss during aging. Previous work has shown that glucocorticoids compromise the capacity of neurons to survive a variety of metabolic insults. This report extends those observations by showing that ischemic injury to neurons in rat brain is also potentiated by exposure to high physiological titers of glucocorticoids and is attenuated by adrenalectomy. The synergy between ischemic and glucocorticoid brain injury was seen even when glucocorticoid levels were manipulated after the ischemic insult. Pharmacological interventions that diminish the adrenocortical stress response may improve neurological outcome from stroke or cardiac arrest.

Report this publication

Statistics

Seen <100 times