Affordable Access

Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta.

Authors
  • Robinson, B G
  • Emanuel, R L
  • Frim, D M
  • Majzoub, J A
Type
Published Article
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publication Date
Jul 01, 1988
Volume
85
Issue
14
Pages
5244–5248
Identifiers
PMID: 2839838
Source
Medline
License
Unknown

Abstract

Primary cultures of purified human cytotrophoblasts have been used to examine the expression of the corticotropin-releasing hormone (CRH) gene in placenta. We report here that glucocorticoids stimulate placental CRH synthesis and secretion in primary cultures of human placenta. This stimulation is in contrast to the glucocorticoid suppression of CRH expression in hypothalamus. The positive regulation of CRH by glucocorticoids suggests that the rise in CRH preceding parturition could result from the previously described rise in fetal glucocorticoids. Furthermore, this increase in placental CRH could stimulate, via adrenocorticotropic hormone, a further rise in fetal glucocorticoids, completing a positive feedback loop that would be terminated by delivery.

Report this publication

Statistics

Seen <100 times