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Glucocorticoid receptor function is decreased in neutrophils during endotoxic shock.

Authors
  • Bergquist, Maria1
  • Jirholt, Pernilla2
  • Nurkkala, Merja2
  • Rylander, Christian3
  • Hedenstierna, Göran4
  • Lindholm, Catharina2
  • 1 Department of Medical Sciences, The Hedenstierna Laboratory, Uppsala University, Sweden; Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Sweden. Electronic address: [email protected] , (Sweden)
  • 2 Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Sweden. , (Sweden)
  • 3 Department of Anaesthesia & Intensive Care, Sahlgrenska University Hospital, Gothenburg, Sweden. , (Sweden)
  • 4 Department of Medical Sciences, The Hedenstierna Laboratory, Uppsala University, Sweden. , (Sweden)
Type
Published Article
Journal
The Journal of infection
Publication Date
Aug 01, 2014
Volume
69
Issue
2
Pages
113–122
Identifiers
DOI: 10.1016/j.jinf.2014.03.011
PMID: 24657243
Source
Medline
Keywords
License
Unknown

Abstract

The decreased glucocorticoid responsiveness displayed by neutrophils, in combination with their increased numbers, may explain why survival is increased only when dexamethasone treatment is given early during LPS induced shock.

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