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Glomerular mRNA expression of prothrombotic and antithrombotic factors in renal transplants with thrombotic microangiopathy.

Authors
  • Agustian, Putri Andina
  • Bockmeyer, Clemens Luitpold
  • Modde, Friedrich
  • Wittig, Juliane
  • Heinemann, Falko Markus
  • Brundiers, Stephanie
  • Dämmrich, Maximilian Ernst
  • Schwarz, Anke
  • Birschmann, Ingvild
  • Suwelack, Barbara
  • Jindra, Peter Thomas
  • Ahlenstiel, Thurid
  • Wohlschläger, Jeremias
  • Vester, Udo
  • Ganzenmüller, Tina
  • Zilian, Eva
  • Feldkamp, Thorsten
  • Spieker, Tilmann
  • Immenschuh, Stephan
  • Kreipe, Hans Heinrich
  • And 2 more
Type
Published Article
Journal
Transplantation Journal
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
May 27, 2013
Volume
95
Issue
10
Pages
1242–1248
Identifiers
DOI: 10.1097/TP.0b013e318291a298
PMID: 23635876
Source
Medline
License
Unknown

Abstract

The glomerular capillary bed seems to contribute to all subtypes of rTx-TMA by down-regulation of the endothelial transcription factors KLF2 and KLF4, indicating dedifferentiation with subsequent up-regulation of PAI-1 and down-regulation of tPA, resulting in inhibition of local fibrinolysis. Decreased glomerular expression of ADAMTS13 and CD55 could be an additional pathway toward microthrombosis exclusively in HR-TMA.

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