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Global strategies are required to cure and eliminate HBV infection

Authors
  • Revill, Peter
  • Testoni, Barbara
  • Locarnini, Stephen
  • Zoulim, Fabien
Publication Date
Apr 01, 2016
Source
HAL
Keywords
Language
English
License
Unknown
External links

Abstract

Chronic HBV infection results in \\textgreater1 million deaths per year from cirrhosis and liver cancer. No known cure for chronic HBV exists, due in part to the continued presence of transcriptionally active DNA in the nucleus that is not directly targeted by current antiviral therapies. A coordinated approach is urgently needed to advance an HBV cure worldwide, such as those established in the HIV field. We propose the establishment of an International Coalition to Eliminate Hepatitis B Virus (ICE-HBV) to facilitate the formation of international working groups on HBV virology, immunology, innovative tools and clinical trials: to promote awareness and education as well as to drive changes in government policy and ensure funds are channelled to HBV cure research and drug development. With the ICE-HBV in place, it should be possible to enable a HBV cure within the next decade

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