Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Global proteomics and pathway analysis of pressure-overload-induced heart failure and its attenuation by mitochondrial-targeted peptides.

Authors
Type
Published Article
Journal
Circulation Heart Failure
1941-3297
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Volume
6
Issue
5
Pages
1067–1076
Identifiers
DOI: 10.1161/CIRCHEARTFAILURE.113.000406
PMID: 23935006
Source
Medline
Keywords
License
Unknown

Abstract

This study elucidates the signaling pathways significantly changed in pressure-overload-induced heart failure. The global attenuation of TAC-induced proteomic alterations by the mitochondrial-targeted peptide SS31 suggests that perturbed mitochondrial function may be an upstream signal to many of the pathway alterations in TAC and supports the potential clinical application of mitochondrial-targeted peptide drugs for the treatment heart failure.

Statistics

Seen <100 times