Global proteomics and pathway analysis of pressure-overload-induced heart failure and its attenuation by mitochondrial-targeted peptides.
- Authors
- Type
- Published Article
- Journal
- Circulation Heart Failure
- Publisher
- Ovid Technologies Wolters Kluwer -American Heart Association
- Publication Date
- Sep 01, 2013
- Volume
- 6
- Issue
- 5
- Pages
- 1067–1076
- Identifiers
- DOI: 10.1161/CIRCHEARTFAILURE.113.000406
- PMID: 23935006
- Source
- Medline
- Keywords
- License
- Unknown
Abstract
This study elucidates the signaling pathways significantly changed in pressure-overload-induced heart failure. The global attenuation of TAC-induced proteomic alterations by the mitochondrial-targeted peptide SS31 suggests that perturbed mitochondrial function may be an upstream signal to many of the pathway alterations in TAC and supports the potential clinical application of mitochondrial-targeted peptide drugs for the treatment heart failure.
