Global discovery of lupus genetic risk variant allelic enhancer activity

Authors

• Lu, Xiaoming¹
• Chen, Xiaoting¹
• Forney, Carmy¹
• Donmez, Omer¹
• Miller, Daniel¹
• Parameswaran, Sreeja¹
• Hong, Ted^{1, 2, 3}
• Huang, Yongbo¹
• Pujato, Mario^{4, 5}
• Cazares, Tareian⁴
• Miraldi, Emily R.^{4, 4, 6}
• Ray, John P.^{7, 8}
• de Boer, Carl G.^{7, 9}
• Harley, John B.^{1, 4, 6, 10, 4}
• Weirauch, Matthew T.^{1, 4, 6, 4, 4}
• Kottyan, Leah C.^{1, 4, 6, 4}

• ¹ Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA , Cincinnati (United States)
• ² University of Cincinnati, College of Medicine, Cincinnati, OH, USA , Cincinnati (United States)
• ³ R&D Oncology, AstraZeneca, Boston, MD, USA , Boston (United States)
• ⁴ Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA , Cincinnati (United States)
• ⁵ Production Informatics, Oncology, AstraZeneca, Gaithersburg, MD, USA , Gaithersburg (United States)
• ⁶ University of Cincinnati College of Medicine, Cincinnati, OH, USA , Cincinnati (United States)
• ⁷ Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA, USA , Cambridge (United States)
• ⁸ Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA , Washington (United States)
• ⁹ University of British Columbia, Vancouver, BC, Canada , Vancouver (Canada)
• ¹⁰ US Department of Veterans Affairs Medical Center, Cincinnati, OH, USA , Cincinnati (United States)

Type

Published Article

Journal

Nature Communications

Publisher

Springer Nature

Publication Date

Mar 12, 2021

Volume

12

Issue

1

Identifiers

DOI: 10.1038/s41467-021-21854-5

Source

Springer Nature

License

Green