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Glioma induced alterations in fecal short-chain fatty acids and neurotransmitters

Authors
  • Dono, Antonio1, 2
  • Patrizz, Anthony1
  • McCormack, Ryan M1
  • Putluri, Nagireddy3
  • Ganesh, Bhanu P4
  • Kaur, Balveen1
  • McCullough, Louise D4
  • Ballester, Leomar Y1, 2, 5
  • Esquenazi, Yoshua1, 5, 6
  • 1 77030, USA
  • 2 Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
  • 3 Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, TTX 77030, USA
  • 4 Department of Neurology, The University of Texas Health Science Center at Houston, Houston, TTX 77030, USA
  • 5 Memorial Hermann Hospital-TMC, Houston, TX 77030, USA
  • 6 Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TTX 77030, USA
Type
Published Article
Journal
CNS Oncology
Publisher
Future Medicine
Publication Date
Jun 30, 2020
Volume
9
Issue
2
Identifiers
DOI: 10.2217/cns-2020-0007
PMID: 32602743
PMCID: PMC7341178
Source
PubMed Central
Keywords
License
Green

Abstract

Aim: To explore fecal short-chain fatty acids and neurotransmitter alterations in a mouse–glioma model and glioma patients. Methods: Liquid chromatography–mass spectrometry and 16S rRNA-sequencing from fecal samples were performed to measure metabolite levels and taxa abundance in mice/humans. Mice underwent GL261 implantation with/without temozolomide. Glioma patients were compared with healthy controls. Results: Glioma altered several short-chain fatty acids and neurotransmitter levels. Reduced 5-hydroxyindoleaceic acid and norepinephrine levels were seen in mice and humans. Interestingly, temozolomide treatment abrogates the effects of glioma on fecal metabolites. Conclusion: Our findings demonstrate the interplay between glioma and the gut–brain axis. Further work is required to identify pathways within the gut–brain axis by which glioma influences and promotes the modulation of fecal metabolites and microbiome.

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