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Glioblastoma formation in a recurrent intracranial epidermoid cyst: a case report

Authors
  • MacMahon, Paul1, 2, 1, 2
  • Labak, Collin M3, 3
  • Martin-Bach, Sarah E4, 5, 4, 5
  • Issawi, Ahmad1, 2, 1, 2
  • Velpula, Kiran3, 3
  • Tsung, Andrew J1, 2, 3, 1, 2, 3
  • 1 Department of Neurosurgery, University of Illinois College of Medicine at Peoria, Peoria, IL, 61605, USA
  • 2 Neurosurgery Department, OSF HealthCare Illinois Neurological Institute, Peoria, IL, 61637, USA
  • 3 Department of Cancer Biology & Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL, 61605, USA
  • 4 Department of Pathology, University of Illinois College of Medicine at Peoria, Peoria, IL, USA
  • 5 Neuropathology, OSF HealthCare Illinois Neurological Institute, Peoria, IL, 61637, USA
Type
Published Article
Journal
CNS Oncology
Publisher
Future Medicine
Publication Date
Dec 13, 2018
Volume
7
Issue
4
Identifiers
DOI: 10.2217/cns-2018-0002
PMID: 30543115
PMCID: PMC6331695
Source
PubMed Central
Keywords
License
Green

Abstract

Background: Transformation to glioblastoma following recurrent epidermoid cyst resection has not been reported. Chronic inflammation can underlie malignant transformation of epidermoid cysts. Astrogliosis following repeated resections may have induced the rare transformation to glioblastoma. Clinical presentation: A patient presenting with left lower extremity weakness was found to harbor a parietal mass lesion. Histopathology demonstrated an epidermoid cyst. Following multiple re-resections, an intra-axial mass was discovered within the operative bed, confirmed as glioblastoma. Conclusion: This is the first report of glioblastoma associated with a resected epidermoid cyst. Subsequent to resection, the chronic inflammatory milieu propagated by astrogliosis is thought to have induced malignancy. The progression to glioblastoma draws attention to neoplastic transformation in the context of recurrent epidermoids.

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