Affordable Access

deepdyve-link
Publisher Website

Glia-derived exosomes: Promising therapeutic targets.

Authors
  • Li, He1
  • Luo, Yin2
  • Zhu, Luojiang1
  • Hua, Weilong1
  • Zhang, Yongxin3
  • Zhang, Hongjian3
  • Zhang, Lei4
  • Li, Zifu3
  • Xing, Pengfei4
  • Zhang, Yongwei4
  • Hong, Bo3
  • Yang, Pengfei3
  • Liu, Jianmin5
  • 1 Changhai Stroke Center, Changhai Hospital, Second Military Medical University, Shanghai, China; Graduate School, Second Military Medical University, Shanghai, China. , (China)
  • 2 Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China. , (China)
  • 3 Changhai Stroke Center, Changhai Hospital, Second Military Medical University, Shanghai, China; Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China. , (China)
  • 4 Changhai Stroke Center, Changhai Hospital, Second Military Medical University, Shanghai, China. , (China)
  • 5 Changhai Stroke Center, Changhai Hospital, Second Military Medical University, Shanghai, China; Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Life sciences
Publication Date
Dec 15, 2019
Volume
239
Pages
116951–116951
Identifiers
DOI: 10.1016/j.lfs.2019.116951
PMID: 31626787
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Glia is an important component of the nervous system that is involved in neurotransmitter uptake, signal transduction, myelin synthesis, neurodevelopment, and immune response. Exosomes are extracellular vesicles that are secreted from certain types of cells, and are known to mediate glia function. Glia-derived exosomes (GDEs) can transport proteins, nucleotides and cellular waste, and exert both protective and toxic effects on the nervous system. GDEs promote glia-neuron communication, anti-stress responses, anti-inflammation and neurite outgrowth, and may also be involved in neurological disease such as glioma, glioblastoma, Alzheimer's disease, Parkinson disease and neuronal HIV infections. This review summarizes the current research on GDEs and their functions, with emphasis on their therapeutic potential. Copyright © 2019 Elsevier Inc. All rights reserved.

Report this publication

Statistics

Seen <100 times