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Gli-1 siRNA induced apoptosis in Huh7 cells.

Authors
  • Chen, Xi-Lin
  • Cao, Liang-Qi
  • She, Miao-Rong
  • Wang, Qian
  • Huang, Xiao-Hui
  • Fu, Xin-Hui
Type
Published Article
Journal
World Journal of Gastroenterology
Publisher
Baishideng Publishing Group Co
Publication Date
Jan 28, 2008
Volume
14
Issue
4
Pages
582–589
Identifiers
PMID: 18203291
Source
Medline
License
Unknown

Abstract

Down-regulation of Bcl-2 plays an important role in apoptosis induced by Gli-1 siRNA in HCC cells. Combination Gli-1 siRNA with chemotherapeutic drug could represent a more promising strategy against HCC. The effects of the strategies need further investigation in vivo and may have potential clinical application.

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