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Glaciapyrroles A, B, and C, pyrrolosesquiterpenes from a Streptomyces sp. isolated from an Alaskan marine sediment.

Authors
  • Macherla, Venkat R
  • Liu, Jehnan
  • Bellows, Christopher
  • Teisan, Sy
  • Nicholson, Benjamin
  • Lam, Kin S
  • Potts, Barbara C M
Type
Published Article
Journal
Journal of natural products
Publication Date
May 01, 2005
Volume
68
Issue
5
Pages
780–783
Identifiers
PMID: 15921430
Source
Medline
License
Unknown

Abstract

A Streptomyces sp. (NPS008187) isolated from a marine sediment collected in Alaska was found to produce three new pyrrolosesquiterpenes, glyciapyrroles A (1), B (2), and C (3), along with the known diketopiperazines cyclo(leucyl-prolyl) (4), cyclo(isoleucyl-prolyl) (5), and cyclo(phenylalanyl-prolyl) (6). The structures of 1, 2, and 3 were established using spectroscopic methods.

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