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[Gitoformate and digitoxin as alternatives to kidney-dependent glycosides in the therapy of cardiac insufficiency].

Authors
  • Rietbrock, N
  • Woodcock, B G
  • Hrazdil, U
Type
Published Article
Journal
Arzneimittel-Forschung
Publication Date
Jan 01, 1984
Volume
34
Issue
8
Pages
915–917
Identifiers
PMID: 6541927
Source
Medline
License
Unknown

Abstract

Kidney independent glycosides offer a high measure of therapeutic safety in comparison with kidney dependent glycosides. The intoxication rate lies between 4 and 6%. The pharmacokinetic properties of pentaformylgitoxin (INN: gitoformate) are comparable with those for digitoxin. The active glycoside 16-formylgitoxin (INN: gitaloxin) is formed by rapid deformylation of the formyl residue on the sugar chain. The maintenance dose of 0.06 mg daily, based on the half-life, produces therapeutic concentrations in the range 6-30 ng/ml. The required loading dose, as for digitoxin, amounts to 10 times the maintenance dose.

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