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Ginseng aqueous extract ameliorates lambda-cyhalothrin-acetamiprid insecticide mixture for hepatorenal toxicity in rats: Role of oxidative stress-mediated proinflammatory and proapoptotic protein expressions.

Authors
  • El-Bialy, Badr E S1
  • Abd Eldaim, Mabrouk A2
  • Hassan, Azza3
  • Abdel-Daim, Mohamed M4, 5
  • 1 Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Egypt. , (Egypt)
  • 2 Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Menoufia University, Sheben Elkom, Egypt. , (Egypt)
  • 3 Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt. , (Egypt)
  • 4 Department of Zoology, Science College, King Saud University, Riyadh, Saudi Arabia. , (Saudi Arabia)
  • 5 Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt. , (Egypt)
Type
Published Article
Journal
Environmental toxicology
Publication Date
Sep 30, 2019
Identifiers
DOI: 10.1002/tox.22848
PMID: 31566303
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

This study was carried out to evaluate the protective effects of Panax ginseng aqueous extract (GAE) against hepatorenal toxicity induced by lambda-cyhalothrin-acetamiprid insecticide mixture in rats. A total of 32 male albino rats were assigned into four groups. Normal control group received distilled water. Insecticide control group intoxicated with the insecticide at a dose of 2.14 mg/kg b.wt orally day after day for 45 days. GAE control group was treated with GAE at a dose 200 mg/kg b.wt orally. GAE experimental group was administered GAE 1 hour before insecticide administration. Intoxication of rats with the insecticide caused a significant increase in serum aspartate aminotransferase and alanine aminotransferase activities and urea and creatinine levels as well as malondialdehyde concentration and proteins expression of caspase-3 and induced nitric oxide synthase in hepatic and renal tissues. However, it decreased the serum levels of total protein and globulin and reduced the glutathione content and catalase activity in hepatic and renal tissues. In addition, insecticide induced histopathological alterations in both hepatic and renal tissues. In contrast, GAE modulated insecticide-induced alterations in liver and kidney functions and structures as it ameliorated the effects of insecticide on the above mentioned parameters. These results indicated that GAE was a potent antioxidant agent that could protect rats against insecticide-induced hepatorenal toxicity. © 2019 Wiley Periodicals, Inc.

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