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Giant keratoacanthoma: case report and review of the English literature.

Authors
  • Bogner, Paul N
  • Cheney, Richard T
  • Zeitouni, Nathalie C
Type
Published Article
Journal
American Journal of Dermatopathology
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Mar 01, 2014
Volume
36
Issue
3
Pages
252–257
Identifiers
DOI: 10.1097/DAD.0b013e318291c582
PMID: 23739248
Source
Medline
License
Unknown

Abstract

The giant keratoacanthoma (KA) is a rare variant of KA with a maximum size exceeding 2-3 cm. Like other forms of KA, it has a tendency to spontaneously regress but can cause significant anatomic damage. A 69-year-old male presented to our hospital with a giant KA of the nose that showed complete pathological regression by the time of surgery. Pathology showed dermal scar with keratin granulomas extending through the nasal wall to the respiratory mucosa. A total of 57 similar cases from the English literature were reviewed for comparison. Few provide similar details of histological regression. Literature cases occurred predominately in males (74.1%) with a mean age of 59 years. Head tumors were most common (70.7%) and most were treated by surgery (34.5%) or a combination of surgery and radiotherapy (24.1%). Other treatment modalities reported include methotrexate, 5-fluorouracil, and interferon.

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