Affordable Access

deepdyve-link
Publisher Website

Giant cell tumor of bone with secondary aneurysmal bone cyst-like change producing β-human chorionic gonadotropin.

Authors
  • Fitzhugh, Valerie A
  • Katava, Gordana
  • Wenokor, Cornelia
  • Roche, Natalie
  • Beebe, Kathleen S
Type
Published Article
Journal
Skeletal Radiology
Publisher
Springer-Verlag
Publication Date
Jun 01, 2014
Volume
43
Issue
6
Pages
831–834
Identifiers
DOI: 10.1007/s00256-013-1785-2
PMID: 24362936
Source
Medline
License
Unknown

Abstract

Giant cell tumor of bone is a benign, locally aggressive neoplasm that is composed of sheets of neoplastic mononuclear cells interspersed amongst non-neoplastic, uniformly distributed, osteoclast-like giant cells. They represent approximately 4-5% of primary bone tumors. Rarely, bone tumors have been noted to produce human chorionic gonadotropin, a finding most often reported in osteosarcoma. We present the case of a young woman who presented with a low-level human chorionic gonadotropin level which, after resection of her recurrent giant cell tumor of bone with secondary aneurysmal bone cyst-like change, became undetectable in her blood. Furthermore, cells within the aneurysmal bone cyst component were immunohistochemically positive for β-human chorionic gonadotropin. This is the first report of such a finding in the literature.

Report this publication

Statistics

Seen <100 times