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Getting older can be exhausting.

Authors
  • Mittal, Rohit
  • Ford, Mandy L
  • Coopersmith, Craig M
Type
Published Article
Journal
Critical care (London, England)
Publication Date
Jan 01, 2014
Volume
18
Issue
4
Pages
465–465
Identifiers
DOI: 10.1186/s13054-014-0465-5
PMID: 25184737
Source
Medline
License
Unknown

Abstract

Sepsis is a disease that affects primarily the aged. Although mortality is higher in both older septic patients and aged septic mice, the mechanisms underlying decreased survival in older hosts are incompletely understood. New work by Inoue and colleagues demonstrates persistent inflammation and T-cell exhaustion in older septic patients and aged septic mice. The clinical significance of these findings is manifested not only in increased mortality but also in a marked difference in secondary infections in older patients as long as a month following ICU admission.

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