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Gestational Age-Specific Reference Ranges for the sFlt-1/PlGF Immunoassay Ratio in Twin Pregnancies

Authors
  • De La Calle, Maria
  • Delgado, Juan L.
  • Verlohren, Stefan
  • Escudero, Ana Isabel
  • Bartha, Jose L.
  • Campillos, Jose M.
  • Aguarón De La Cruz, Angel
  • Chantraine, Frederic
  • García Hernández, José Ángel
  • Herraiz, Ignacio
  • Llurba, Elisa
  • Kurka, Hedwig
  • Guo, Ge
  • Sillman, Johanna
  • Hund, Martin
  • Perales Marín, Alfredo
Type
Published Article
Journal
Fetal Diagnosis and Therapy
Publisher
S. Karger AG
Publication Date
Mar 30, 2021
Volume
48
Issue
4
Pages
288–296
Identifiers
DOI: 10.1159/000514378
PMID: 33784677
Source
Karger
Keywords
License
Green
External links

Abstract

Objective: Establish reference ranges for the Elecsys® soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) immunoassay ratio in twin pregnancies. Methods: Data analyzed were from 3 prospective studies: Prediction of Short-Term Outcome in Pregnant Women with Suspected Preeclampsia (PE) (PROGNOSIS), Study of Early-onset PE in Spain (STEPS), and a multicenter case-control study. Median, 5th, and 95th percentiles for sFlt-1, PlGF, and the sFlt-1/PlGF ratios were determined for normal twin pregnancies for 7 gestational windows and compared with the previous data for singleton pregnancies. Results: The reference range analysis included 269 women with normal twin pregnancies. Before 29 weeks’ gestation, median, 5th, and 95th percentiles for sFlt-1/PlGF ratios did not differ between twin and singleton pregnancies. From 29 weeks’ gestation to delivery, median, 5th, and 95th percentiles for sFlt-1/PlGF ratios were substantially higher in twin versus singleton pregnancies. sFlt-1 values were higher in women with twin pregnancies across all gestational windows. PlGF values were similar or higher in twin versus singleton pregnancies; PlGF concentrations increased from 10 weeks + 0 days to 28 weeks + 6 days’ gestation. Conclusions: Reference ranges for the sFlt-1/PlGF ratio are similar in women with twin and singleton pregnancies until 29 weeks’ gestation but appear higher in twin pregnancies thereafter.

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