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Geriatric depression and vascular diseases: what are the links?

Authors
Type
Published Article
Journal
Journal of Affective Disorders
0165-0327
Publisher
Elsevier
Publication Date
Volume
81
Issue
1
Pages
1–16
Identifiers
PMID: 15183594
Source
Medline
License
Unknown

Abstract

Depression can be understood as the direct consequence of brain damage in neurodegenerative disorders such as Parkinson's or Huntington's diseases. Similarly, vascular depression is mostly considered to be the consequence of microvascular lesions on prefrontal and subcortical regions. However, this functional neuroanatomical model offers no explanation for cases where depression has been shown to precede vascular diseases. Since cardiovascular diseases develop in a context of acquired environmental factors together with genetically determined disease, it may be postulated that geriatric depression could both result from brain lesions of vascular origin and also share some pathogenic or genetic determinants.

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