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Geraniin Promotes Recovery of Hematopoietic Cells after Radiation Injury.

Authors
  • Bing, So Jin1
  • Cho, Jinhee1
  • Kim, Areum2
  • Herath, Kalahe Hewage Iresha Nadeeka Mad...2
  • Ahn, Ginnae3
  • Lee, Nam Ho4
  • Park, Jae Woo5
  • Jee, Youngheun1, 2
  • 1 * Department of Veterinary Medicine and Institute for Nuclear Science & Technology, Jeju National University, Jeju 63243, South Korea. , (North Korea)
  • 2 † Department of Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, South Korea. , (North Korea)
  • 3 ‡ Department of Chemistry, College of Natural Sciences, Jeju National University, Jeju 63243, South Korea. , (North Korea)
  • 4 § Department of Nuclear and Energy Engineering, Jeju National University, Jeju 63243, South Korea. , (North Korea)
  • 5 ¶ Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu 59626, South Korea. , (North Korea)
Type
Published Article
Journal
The American journal of Chinese medicine
Publication Date
Jan 01, 2017
Volume
45
Issue
5
Pages
1003–1016
Identifiers
DOI: 10.1142/S0192415X17500537
PMID: 28659035
Source
Medline
Keywords
License
Unknown

Abstract

Cells of the hematopoietic system are uniquely radiosensitive due to their rapid proliferation. Consequently, immune suppression readily and undesirably results from irradiation. Our previous studies demonstrated that geraniin isolated from Nymphaea tetragona var. angusta (water lily) had a protective effect on the splenocytes and intestinal tract of irradiated mice. This study was designed to assess the effectiveness of geraniin, an ellagitannin isolated from the water lily, in decreasing gamma ray irradiation-induced destruction of the hematopoietic system in mice. Geraniin treatment improved the survival time of bone marrow cells and maintained bone marrow integrity and also up-regulated the expression of stem cell receptors and the extent of cell mitosis. Geraniin also enhanced the proliferation and differentiation of immune cells that had been suppressed by irradiation. These results suggest geraniin is a promising agent for reconstituting hematopoietic cells after exposure to irradiation.

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