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[Gentamicin toxicity to animals of both sexes and different ages].

Authors
  • Mangurova, M
  • Zheliazkov, D
  • Belcheva, A
Type
Published Article
Journal
Eksperimentalna meditsina i morfologiia
Publication Date
Jan 01, 1975
Volume
14
Issue
3
Pages
161–165
Identifiers
PMID: 1222710
Source
Medline
License
Unknown

Abstract

Gentamycin acute toxicity in sexually-immature and sexually-mature male and female rats was tested comparatively. DL50 for the female sexually-mature rats was found to be statistically reliable lower than that for the remaining three groups of animals. The greatest differences were observed in the values for the maximum non-lethal and minimum lethal doses of this antibiotic. The authors suggeste the use of a new index for the evaluation of gentamycin acute toxicity called Dose Range Index.

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