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Genomics of Otitis Media (OM): Molecular Genetics Approaches to Characterize Disease Pathophysiology

Authors
  • Giese, Arnaud P. J.1
  • Ali, Saadat2
  • Isaiah, Amal1
  • Aziz, Ishrat3
  • Riazuddin, Saima1
  • Ahmed, Zubair M.1
  • 1 Department of Otorhinolaryngology—Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD , (United States)
  • 2 The Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore , (Pakistan)
  • 3 Department of Biotechnology, Virtual University of Pakistan, Lahore , (Pakistan)
Type
Published Article
Journal
Frontiers in Genetics
Publisher
Frontiers Media SA
Publication Date
Apr 23, 2020
Volume
11
Identifiers
DOI: 10.3389/fgene.2020.00313
PMID: 32391049
PMCID: PMC7191070
Source
PubMed Central
Keywords
License
Unknown

Abstract

Otitis media (OM) is an infective and inflammatory disorder known to be a major cause of hearing impairment across all age groups. Both acute and chronic OM result in substantial healthcare utilization related to antibiotic prescription and surgical procedures necessary for its management. Although several studies provided evidence of genetics playing a significant role in the susceptibility to OM, we had limited knowledge about the genes associated with OM until recently. Here we have summarized the known genetic factors that confer susceptibility to various forms of OM in mice and in humans and their genetic load, along with associated cellular signaling pathways. Spotlighted in this review are fucosyltransferase (FUT) enzymes, which have been implicated in the pathogenesis of OM. A comprehensive understanding of the functions of OM-associated genes may provide potential opportunities for its diagnosis and treatment.

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